Go with the TSi300s. The D'Appolito configuration tends to produce much more coherent soundstages with better off-axis imaging (i.e. a bigger "sweet spot"). They're also not bass-reflex, for which I have a personal dislike. Since you've got a powered sub, the loss of low-frequency efficiency in an acoustic suspension speaker like the TSi300 will largely be mitigated by the speakers never seeing all the LF content.
If the powered sub has a variable crossover frequency, once you've got the system up and running twiddle with that with an eye to bringing the crossover frequency as low as possible without losing the midbass from the main speakers.
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