Now, my system's in the sig, and for almost a year it's been running a pretty high overclock right across the board:
Athlon II 640 - Clocked to 3.75Ghz
Memory - Clocked to 1866
Crossfire Radeon HD 5770's - Clocked to 930 Mhz (Core), 1350 Mhz (Memory) on both
I ran thru a few scenes in both games 3 times the best I could consistently, and used Radeon Pro to capture the frame rates - It was then averaged. All games were run at 1920 X 1200, Detail setting in Crysis 2 was simply set to "Extreme", and in Test Drive 2 I moved every detail slider to "Very High", Set AA to 4x, and Aniso to 16x. Here's the scores:
Crysis 2: 27 FPS
Test Drive 2: 18 FPS
I clock everything back to stock speeds (nothing was overheating btw) - CPU at 3Ghz, Memory to 1333Mhz and GPU's to 850 Core, 1200 Memory:
Crysis 2: 39 FPS
Test Drive 2: 34 FPS
Other games like Batman AA, AvP or anything Source Engine based see FPS increases with the overclock still, but the 2 games above break with tradition and run worse if the system is overclocked. Colour me confused - Anyone seen this before?

