A mobo replacement should only occur with a complete reinstall. That said, Windows has been getting better at this over the years and you may have no issues. If you just swap and let Windows figure things out on its own, be prepared to reinstall at the first signs of flakiness.
There are people that embrace the Oxford comma and people who don't. Never get between these people when drink has been taken. I use the Oxford comma and always will. The rest can sod off.