While I am not new to having multiple displays, I am to having them mismatched. My main screen is a 37" LCD TV in normal orientation (1920x1080) and I just hooked up a second monitor that is a 24" LCD that I have in portrait mode (1200x1920). I actually looks pretty good as the physical screen sizes are pretty close when oriented this way. Plus I love being able to throw a wall of text up on the portrait screen.
My complaint is that when transitioning from screen to screen the mouse hits a brick wall and wont move over to the other screen unless I travel a significant distance. I know this is "normal" behavior and usually it's not enough to matter. With this layout though the bottom of my LCD TV is a little past the middle of the LCD monitor according to windows (again, not physically). So if I need to transition my mouse from the LCD monitor to the TV I have to bring it a little less than halfway up the screen before it will show up on the TV. This is rather annoying, obviously. I can play with the positioning of the screens and have them centered to each other but then I still have roughly 20% of the screen on top and bottom that don't align in mouse world.
Is there any multimonitor software packages out there that will allow you to do mouse transitions that match more closely with the physical world?