I have been getting some issues with that. Initially, I installed my OS on the SSD. When I loaded up Windows, my 1TB HDD didn't show up. Eventually, I learned that I need to format it using DIsk Management. However, I loaded it as a B drive. Apparently, when I tried to install Diablo 3, it wouldn't let me because the B drive is normally reserved for floppy disks. So I had to remap the drive as the E drive instead. Now everything is a mess. My library folders are now just normal folders. I can't even change the location. For example, I can go into the E drive, open properties on "My Document" and it won't give me the option to remap its location. To show you what I mean, here's a picture:
Because of this, I couldn't move my Downloads, Music, My Documents, etc folders back to my C/User/Mike folder because I wanted to move them back there then relink them to a new location on my E drive. This way, there will be shortcuts for those folders on the C drive but their actual location will be on the E drive. In the end, I had to resorted to doing this:
Another problem that I ran into was some issues with rainmeter. Rainmeter worked well, even after the switch. However, after I restarted my computer a couple of time to install Windows updates, I get this:
I can install and reinstall Rainmeter as much time as I want, to my Program Files 2 folder (the one on my E drive), to my Program Files, or even Program Files (x86) and I would get the same error message. I can't install any of my skins now and Rainmeter doesn't boot up at launch automatically anymore, no matter how hard I try to get it to.
My Nexus Mod Manager also doesn't work anymore. It crashes everything I boot it up. Reinstalling doesn't help. I can't uninstall any of the mods I installed on Skyrim using it. I'm thinking of deleting Skyrim and everything inside the folder and reinstall NMM and Skyrim. I'm guessing the mods are preventing the NMM from booting up.
Another issue that I ran across had to do with LA Noir. Essentially, LA Noir tells me that it can't create a save directory and thus can't start. I'm assuming that has to do with my remapped drive.
A quick note but whenever I plugged my external HDD into my computer, it usually takes up the E drive. I mapped my HDD to the E drive for convenience sake because I didn't want it to be behind my external harddrives. Should I have mapped it to something like the G drive instead? I'm assuming all of these issues stemmed from the fact that I mapped it wrong.