I think I got it--turned out to be multiple issues, and I'm still not sure what's up exactly.
Somehow I think Asus GPU Tweak II was involved in crashing other games...though it worked just fine prior to 1803 update. As for Hellblade, there's apparently something going on there with Unreal Engine and Nvidia drivers. Going back to 381.65 allowed me to load the game, whereas about a half dozen other more recent driver versions did nothing.
The GPU Tweak bit is pretty weird--when allowing to load at startup it'd show stuff like GPU Speed 190%, and then it'd disappear, click on presets and it'd snap to what it is supposed to. 111% for OC mode, 109% for gaming, 107% silent--and no, the user profile wasn't set to anything crazy like 190%. I haven't the slightest idea what's going on there, but just shutting it down let me load various other games minus Hellblade. Never had an issue with it before. 1803 thing, driver thing, no idea.
Thanks again, everyone.