She has two 24" monitors on her desk so any ideas about putting the case behind them is a no go. I suggested the monitors on arms/brackets already and that got shot down as well.
A better approach to this topic would be for you to list every component she has so that we can suggest cases that will house everything. It sounds like some good case ideas are being thrown around here, but nobody knows if all of her components will fit inside.
Her system is a copy of mine with some extras and larger HDD's.
Intel Core i5-3570K
ASUS P8Z77-V LK LGA 1155 Intel Z77 Motherboard
CORSAIR Vengeance LP 32GB (4 x 8GB)
EVGA 02G-P4-2680-KR GeForce GTX 680 2GB
2x SAMSUNG 830 Series MZ-7PC512D/AM 2.5" 512GB
Seagate Barracuda ST1000DM003 1TB 7200 RPM 64MB Cache SATA 6.0Gb/s 3.5" Internal Hard Drive
SeaSonic Platinum Platinum-860 860W ATX12V
SAMSUNG DVD Burner 24X DVD+R 8X DVD+RW
Corsair Special Edition White Graphite Series 600T
COOLER MASTER GeminII S524 120mm Long Life Sleeve CPU Cooler
Her system has everything mine has plus three 4TB HDD instead of the one 1TB in mine, a 840 pro 256GB SSD as a boot drive, two GTX 680's compared to my one, a ASUS sound card, a PCIe USB adapter card, two DVD burners, a Blu ray Burner, and a all in one card reader for the last 5.25 bay.
Since some of this stuff is work related I have put the idea in her head that we should be looking at separating out what she needs for work into a case like she wants and could keep the tower for the gaming system and move it into her living room where she could game and watch videos from the comfort of her recliner.
She is finally realizing what she wanted wasn't practical. There is no way we are going to fit her current system into a HTPC case and not have heat issues, assuming we could find a case to fit all that into any way.