A "NUC" form factor with one of these parts will certainly not be passively cooled like some of the smaller NUCs out there, but it's not like cooling 50 - 100 watts in a small package is completely out of the question. One advantage of the way these chips are packaged is that it's pretty easy to get the mounting plate of the cooler to cover both the CPU and GPU with a single unit.
4770K @ 4.7 GHz; 32GB DDR3-2133; GTX-1080 sold and back to hipster IGP!; 512GB 840 Pro (2x); Fractal Define XL-R2; NZXT Kraken-X60
--Many thanks to the TR Forum for advice in getting it built.