You shouldn't have any issues. As long as you aren't suddenly killing power while seeking/writing it usually isn't going to hurt the drive anyway.
Heh, that is my "hope!"... that windows will "uninstall" or "offline" a drive in a data safe manner.
Also the thought of plugging an edge connecter into a slot that may or may not be hot is....
Like updating a bios, 22 bios updates behind. From Nov 11-11 to July-28-14.
32 months and 22 bios updates. Average 1.4 months per bios update...
I am not doing that!
If I ever see the bios seem to stabilize for a while or I move to a
newer operating system I will. (cringe)