I think it is silly, even downright absurd, that computer enthusiasts are so obsessed with system performance to buy high-end hardware or upgrade less than 3 year old systems, yet then the system never gets utilized to its potential. This goes doubly-so for overclockers, overclocking a modern CPU alone is nice, but how about actually quantifying the difference in a fashion that isn't a 5 minute benchmark? I got into Folding partly for altruistic reasons and partly to see what my hardware could do after I overclocked the heck out of it. If I could run F@H 24/7 on a 100% overclocked E6300 (3.8Ghz) without crashes then I knew it was stable, and took it as a point of pride as well. And I enjoyed seeing what the OC actually gained out of the same hardware.
I don't OC much anymore, I'll take the free max turbo bin OC across all cores and leave it at that for power consumption reasons. But I still fold because the system is running 24/7 already for other reasons and it's for a good cause. The cause has had quantifiable results and seems more realistic than others such as SETI (which was the first DC project I got started on). It helps that EVGA actually incentivizes folding with a monthly account credit, I've been folding for so long that when Pascal shows up I could get a Hydro model flagship card for free, if ignoring all those past power bills.
I plan to skip Titan P and will look at Titan V whenever Volta comes around, but it's nice to have the option available. EVGA's credit doesn't completely offset folding costs, but it's still a nice touch. http://www.evga.com/folding/promo.asp
As for hardware durability... I've run a GTX 480 FTW Hydro for five years, literally 24/7 folding when not gaming. The card still runs fine, and everyone knows how hot 480's were nevermind FTW models. That E6300 system I mentioned above also runs fine though I stuck it at 3Ghz and replaced my father's email rig with it. Anyone that plans to do sustained GPU folding should either be using a watercooled card or have a lifetime warranty to fall back on... when/if the GTX 480 croaks I'll just send it in for warranty. Just another reason why lifetime warranties are no longer a thing (and why I didn't care about folding it into the ground).