Personal computing discussed
Moderators: renee, farmpuma, just brew it!
JustAnEngineer wrote:No work units at all in the past 22 hours ( 2 GPU and 1 CPU slots).
DPete27 wrote:Well, that escalated quickly.
F@H just broke the exaFLOP barrier. Now larger than the top 100 supercomputers in the world combined.
P.S.: I updated from version 7.5.1 to the new version 7.6.9 and it seems to be working fine. Right at this moment, all three slots are crunching away at work units.In response to popular demand, we have created an update to the Folding@home software that allows you to prioritize COVID-19 projects. We encourage you to upgrade as the new software includes important bug fixes and security updates. Downloads are available at
https://foldingathome.org/start-folding/
Please also join me in thanking the Center for the Science and Engineering of Living Systems (CSELS) at Washington University in St. Louis for funding the development of this software update.
Looking towards the future, we are also working on a new Open-Source Folding@home software. This new software will improve the performance of Folding@home and make it easier to get the community involved in its development. By tapping into the massive amount of technical talent available in the Folding@home community, we believe we can produce better software with a more engaging and productive user experience and update that software more often.
Cool stuff!Coronavirus (CoV) has a capsid that envelops the single-stranded RNA genome. Three structural proteins are shown to be associated with the capsid: membrane, envelope, and the spike protein. Chemical compounds and monoclonal antibodies that target SARS-CoV-2 surface proteins have been under investigation for treating COVID-19. In addition, new vaccines targeting the viral surface antigens are under intense development for the prevention of COVID-19. Unfortunately, drugs and vaccines with inhibitory mechanisms targeting surface receptors may not be effective due to the constant evolution of surface receptors to acquire drug resistance and evade host immune response. In contrast, viral RNA-dependent-RNA polymerase (RdRp) is a protein that is deeply buried inside the viral capsule and is responsible for viral replication. Furthermore, the functional conservation of the RdRp renders it highly resistant to mutations. Hence, RdRp serves as a promising drug target.
Developing drugs targeting SARS-CoV-2 RdRp is a challenging task due to its intrinsic proof-reading exonuclease (ExoN) function. The replicase polyprotein of coronaviruses is a multifunctional protein that contains 16 non-structural proteins (nsp). Among them, nsp12 is the core catalytic subunit responsible for the nucleotide addition (see Fig. 1a). If nsp12 made an error to incorporate a mismatched nucleotide, nsp14-ExoN will correct the mistake by cleaving this mis-incorporated nucleotide (see Fig. 1b). NTP analogs can inhibit the catalytic core subunit of nsp12, but to counteract NTP analogs incorporation into the nascent RNA, nsp14’s intrinsic proofreading function removes the incorporated NTP analogue. Remdesivir is a promising drug candidate to treat COVID-19 infection largely due to its ability to inhibit both nucleotide addition (nsp12) and cleavage (nsp14).
Figure 1: Viral replication enzymes in SARS-CoV-2. (a) nsp12 for nucleotide addition, (b) nsp14 for proofreading via nucleotide cleavage.
The Huang lab from the Hong Kong University of Science and Technology has released a series of Folding@Home projects to simulate the nsp12 and nsp14 complex. We will screen existing FDA-approved NTP analog drugs. We aim to repurpose drugs that can inhibit SARS-CoV-2 replication.
JustAnEngineer wrote:I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.
JustAnEngineer wrote:I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.
Dizik wrote:JustAnEngineer wrote:I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.
I'm not sure if it's just anecdotal, but I seem to get more WUs for my GPU after rebooting my computer. I'll check my logs and see multiple entries of ":WARNING:WU01:FS01:Failed to get assignment", but will automagically get a WU after a reboot. I'm about to upgrade from v7.5.1 to v7.6.9, so hopefully that will help.
G8torbyte wrote:Yeah, I'm in the market as well for a RTX 3080. Outlook looks bleak with an unknown wait time till supplies meet demand. I keep an unRAID server on usually running F@H in the background 24/7 most weeks. It does not have a GPU so it is only crunching a few CPU work units at a time. If there is a drive to boost the folding for Frankenbot next month I'll fire up my other backup servers and PCs that have Pascal and Turing cards.