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Redocbew
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Re: TRFrankenbot for COVID-19

Sun Apr 05, 2020 4:00 pm

I seem to be getting mostly CPU units also. I haven't been watching things super closely, but most of the time when I've checked on the machine the CPU is crunching away while the GPU is sitting idle. This morning the machine was idle altogether, but that'll change once it's able to pick up some work.
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G8torbyte
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Re: TRFrankenbot for COVID-19

Mon Apr 06, 2020 1:13 pm

I noticed the shift in focus as well. More CPU projects going toward coronavirus research. I'm getting work units fairly consistent each day now. Mostly CPU projects with a few working the GPUs on the older protein folding simulations. Keep'em coming F@H, glad to help any way possible.
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The Swamp
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Re: TRFrankenbot for COVID-19

Tue Apr 07, 2020 12:52 pm

Is anyone getting video card WUs? Best that I can tell, I haven't gotten one since the weekend. My card has been sitting idle after dozens of attempts to get a WU. I'm getting CPU units, but that's it.
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Redocbew
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Re: TRFrankenbot for COVID-19

Tue Apr 07, 2020 12:55 pm

I got a few GPU units while I left the machine on overnight, but it had been pretty much CPU only for a few days before that.
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JustAnEngineer
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Re: TRFrankenbot for COVID-19

Tue Apr 07, 2020 3:45 pm

No work units at all in the past 22 hours ( 2 GPU and 1 CPU slots).
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The Swamp
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Re: TRFrankenbot for COVID-19

Tue Apr 07, 2020 4:09 pm

JustAnEngineer wrote:
No work units at all in the past 22 hours ( 2 GPU and 1 CPU slots).


Try setting the folding power to medium. I find that, for some reason, I get more work units on that setting than on full.
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Topinio
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Re: TRFrankenbot for COVID-19

Thu Apr 09, 2020 6:02 pm

DPete27 wrote:
Well, that escalated quickly.
F@H just broke the exaFLOP barrier. Now larger than the top 100 supercomputers in the world combined.

Now it actually has:
1.18 EFLOPS, or 2.36 "x86 EFLOPS"

"x86 FLOPS" are an estimate of how many FLOPS would have been needed on a set of (undefined) x86 class CPUs (of unknown vintage and capabilities) to do the same amount of work.

8)

Have belatedly kicked off a few runs myself.
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JustAnEngineer
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Re: TRFrankenbot for COVID-19

Mon Apr 13, 2020 6:18 pm

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DPete27
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Re: TRFrankenbot for COVID-19

Tue Apr 14, 2020 10:42 am

^ Yeah!
I thought it was interesting too that they're taking in roughly 6TB/hr of completed computations.

Seems GPU WUs are still pretty scarce, but my CPU seems to get WUs pretty consistently. I'm guessing the CPU WUs are easier to program out?
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Bigbloke
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Re: TRFrankenbot for COVID-19

Wed Apr 15, 2020 12:19 pm

Another day with next to no GPU units. I really want to help, but I can only crunch GPU units (Dual core i3 7350K machine OK for my gaming needs, but not CPU heavy). I don't want to leave machine on all day if it's not got work to do. :(
 
Redocbew
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Re: TRFrankenbot for COVID-19

Wed Apr 15, 2020 12:30 pm

It's been getting better here with the GPU units. Still a bit hit or miss, but better than it was.
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JustAnEngineer
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Re: TRFrankenbot for COVID-19

Sat Apr 18, 2020 7:00 am

https://foldingathome.org/2020/04/17/ne ... -projects/
In response to popular demand, we have created an update to the Folding@home software that allows you to prioritize COVID-19 projects. We encourage you to upgrade as the new software includes important bug fixes and security updates. Downloads are available at
https://foldingathome.org/start-folding/
Please also join me in thanking the Center for the Science and Engineering of Living Systems (CSELS) at Washington University in St. Louis for funding the development of this software update.
Looking towards the future, we are also working on a new Open-Source Folding@home software. This new software will improve the performance of Folding@home and make it easier to get the community involved in its development. By tapping into the massive amount of technical talent available in the Folding@home community, we believe we can produce better software with a more engaging and productive user experience and update that software more often.
P.S.: I updated from version 7.5.1 to the new version 7.6.9 and it seems to be working fine. Right at this moment, all three slots are crunching away at work units.


https://foldingathome.org/2020/04/13/ne ... plication/
Coronavirus (CoV) has a capsid that envelops the single-stranded RNA genome. Three structural proteins are shown to be associated with the capsid: membrane, envelope, and the spike protein. Chemical compounds and monoclonal antibodies that target SARS-CoV-2 surface proteins have been under investigation for treating COVID-19. In addition, new vaccines targeting the viral surface antigens are under intense development for the prevention of COVID-19. Unfortunately, drugs and vaccines with inhibitory mechanisms targeting surface receptors may not be effective due to the constant evolution of surface receptors to acquire drug resistance and evade host immune response. In contrast, viral RNA-dependent-RNA polymerase (RdRp) is a protein that is deeply buried inside the viral capsule and is responsible for viral replication. Furthermore, the functional conservation of the RdRp renders it highly resistant to mutations. Hence, RdRp serves as a promising drug target.

Developing drugs targeting SARS-CoV-2 RdRp is a challenging task due to its intrinsic proof-reading exonuclease (ExoN) function. The replicase polyprotein of coronaviruses is a multifunctional protein that contains 16 non-structural proteins (nsp). Among them, nsp12 is the core catalytic subunit responsible for the nucleotide addition (see Fig. 1a). If nsp12 made an error to incorporate a mismatched nucleotide, nsp14-ExoN will correct the mistake by cleaving this mis-incorporated nucleotide (see Fig. 1b). NTP analogs can inhibit the catalytic core subunit of nsp12, but to counteract NTP analogs incorporation into the nascent RNA, nsp14’s intrinsic proofreading function removes the incorporated NTP analogue. Remdesivir is a promising drug candidate to treat COVID-19 infection largely due to its ability to inhibit both nucleotide addition (nsp12) and cleavage (nsp14).
Figure 1: Viral replication enzymes in SARS-CoV-2. (a) nsp12 for nucleotide addition, (b) nsp14 for proofreading via nucleotide cleavage.

The Huang lab from the Hong Kong University of Science and Technology has released a series of Folding@Home projects to simulate the nsp12 and nsp14 complex. We will screen existing FDA-approved NTP analog drugs. We aim to repurpose drugs that can inhibit SARS-CoV-2 replication.
Cool stuff!
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JustAnEngineer
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Re: TRFrankenbot for COVID-19

Mon Apr 20, 2020 3:51 pm

I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.
· R7-5800X, Liquid Freezer II 280, RoG Strix X570-E, 64GiB PC4-28800, Suprim Liquid RTX4090, 2TB SX8200Pro +4TB S860 +NAS, Define 7 Compact, Super Flower SF-1000F14TP, S3220DGF +32UD99, FC900R OE, DeathAdder2
 
G8torbyte
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Re: TRFrankenbot for COVID-19

Mon Apr 20, 2020 8:11 pm

JustAnEngineer wrote:
I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.


Agree, its been doing well last few days. We've been among the top 5 daily producers lately. The recent software update of F@H version 7.6.9 is better in allowing to prioritize COVID-19 work units.
Later, -G8tor
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The Swamp
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Re: TRFrankenbot for COVID-19

Tue Apr 21, 2020 2:01 pm

I've noticed it's gotten a lot better, too. I'm back in the top 20 producers! I kicked Revol off. Sorry, man.
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blastdoor
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Re: TRFrankenbot for COVID-19

Tue Apr 21, 2020 4:19 pm

With the latest client and after some tinkering with configurations, it's looking like I might be able to produce better than 300k PPD (when my computer isn't being used for work, that is).
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Dizik
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Re: TRFrankenbot for COVID-19

Thu Apr 23, 2020 10:16 am

JustAnEngineer wrote:
I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.

I'm not sure if it's just anecdotal, but I seem to get more WUs for my GPU after rebooting my computer. I'll check my logs and see multiple entries of ":WARNING:WU01:FS01:Failed to get assignment", but will automagically get a WU after a reboot. I'm about to upgrade from v7.5.1 to v7.6.9, so hopefully that will help.
Heavy is good, heavy is reliable. If it doesn't work, you can always hit them with it.
 
The Swamp
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Re: TRFrankenbot for COVID-19

Fri Apr 24, 2020 7:14 am

Dizik wrote:
JustAnEngineer wrote:
I've been getting more work units in the past couple of days. Today could be the first time in more than two weeks that my folding slots get close to full utilization.

I'm not sure if it's just anecdotal, but I seem to get more WUs for my GPU after rebooting my computer. I'll check my logs and see multiple entries of ":WARNING:WU01:FS01:Failed to get assignment", but will automagically get a WU after a reboot. I'm about to upgrade from v7.5.1 to v7.6.9, so hopefully that will help.


Rebooting restarts the folding app. You don't have to reboot. Just shut down the app and restart it manually. The problem with the app is that once it's tried a few times to download a WU, it will stop trying for longer and longer periods of time. Eventually, it will be hours in between attempts to retrieve a new WU. There's where you lose all of your time and points. Restarting the app resets the retrieval clock and you usually get a WU pretty quickly after that.
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Bigbloke
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Re: TRFrankenbot for COVID-19

Fri Apr 24, 2020 11:45 am

^ You can also pause the folding (even though it isn't actually folding) and un-pause after a brief delay, and it restarts the timeout clock. Might be easier than quitting the app, and restarting.
 
BIF
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Re: TRFrankenbot for COVID-19

Sun Sep 27, 2020 12:23 pm

I have been wanting to get back into folding, but I'm waiting for the F@H client to receive optimizations for the RTX 3080 (or whatever) is, well if any were available.

I still have a couple of old GTX 980s, that I want to replace with a couple of 3080 cards. But 3080s have a huge supply problem right now, so I'm waiting, waiting, waiting.

The 980 fans are just too loud and the home office too warm when folding for me to even be nearby. And with covid we're all in our home offices all the time now, so I don't even have a few days each week where I could elect to go into the work office.

I know some of you are using Frankie's key year-round for Covid, and that's great because the more folders, the better! But I'm one of those who fold under a different name except for October. When I'm folding, that is.

Anyhow, are we thinking about ramping up Frankie for the month of October?
 
G8torbyte
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Re: TRFrankenbot for COVID-19

Sun Sep 27, 2020 3:44 pm

Yeah, I'm in the market as well for a RTX 3080. Outlook looks bleak with an unknown wait time till supplies meet demand. I keep an unRAID server on usually running F@H in the background 24/7 most weeks. It does not have a GPU so it is only crunching a few CPU work units at a time. If there is a drive to boost the folding for Frankenbot next month I'll fire up my other backup servers and PCs that have Pascal and Turing cards.
Later, -G8tor
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Krogoth
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Re: TRFrankenbot for COVID-19

Sun Sep 27, 2020 11:24 pm

Customer-tier Ampere is an absolute leviathan at FP32 computing. It'll chomp through WUs that are heavily-depended on it like hot dounts. I expect the RTX 3080-3090 to pull in 2-3 million PPD under such workloads.
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BIF
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Re: TRFrankenbot for COVID-19

Mon Sep 28, 2020 12:17 am

The Nvidia 3080 and 3090 model numbers were also IBM mainframe model numbers. Full circle.
 
Flying Fox
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Re: TRFrankenbot for COVID-19

Mon Sep 28, 2020 11:24 am

G8torbyte wrote:
Yeah, I'm in the market as well for a RTX 3080. Outlook looks bleak with an unknown wait time till supplies meet demand. I keep an unRAID server on usually running F@H in the background 24/7 most weeks. It does not have a GPU so it is only crunching a few CPU work units at a time. If there is a drive to boost the folding for Frankenbot next month I'll fire up my other backup servers and PCs that have Pascal and Turing cards.

CPU WUs are relatively worthless in the F@H pecking order. I have chosen to run Rosetta@Home and World Community Grid's OpenPandemic projects which both use the CPU. OpenPandemic said it is working on GPU versions too though.
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JustAnEngineer
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Re: TRFrankenbot for COVID-19

Mon Sep 28, 2020 12:05 pm

They created a ton of new CPU-only WIs for CoViD-19. Has that research wrapped up? Those units ran well on a Ryzen 5 3600X.
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Re: TRFrankenbot for COVID-19

Mon Sep 28, 2020 11:11 pm

I haven't been catching up with the F@H side since the CPU side has been so worthless with the points. If that's that case that's good. How are the point values for those WUs? (Granted my 10-year old Lynnfield is not going to cut it compared to say a 3600X)
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