Yes, I'm aware of the shortfallings of the 465's architecture but I'm getting two games free (*Mafia 2 and Just cause 2) and am hoping that the folding @ home ppd will be higher due to the better GPGPU Cuda architecture. (Total price was $175 with about $60 or $70 worth of games).
The two free (good) games it certainly a nice bargain.
I personally upgraded from a Radeon 4890 to a GTX460. When gaming, I swear I noticed about a 5 degree dip in temperature in my room. Hopefully the GTX465 doesn't get too warm for you when folding 24/7. Then again, maybe you need a heater in the winter!