As long as your motherboard has a PCIe x16 slot, then the graphics card will be compatible with the motherboard. The more likely issue is whether or not your case can accept the length and height of the graphics card.
The large Antec P280
case that you selected for your build (in this thread
) can accommodate huge cards up to 13" long.
i7-8700K, H100i v2, RoG Strix Z370-G Gaming, 16 GiB, RX Vega64, 960Pro SSD, 5TB HDD, Define Mini-C, SS-660XP2, C32HG70, RK-9000BR, MX518