I generally just go with the built-in firewall and MSE for security, plus Malwarebytes for malware removal (if needed). Unless you're in the habit of visiting questionable web sites, clicking on random links people send you in e-mails, or installing software from untrusted sources, that really ought to be enough (and if you *do* engage on those risky behaviors even the best AV is eventually going to let something slip through).
I used to recommend AVG, but it has gotten quite bloated in the past few years so it is now on my "avoid" list. And avoid anything McAfee like the plague.
I'm not familiar with TuneUp Utilities 2013, but many of these types of tools are little more than digital snake oil. Just make sure you routinely uninstall software you don't use any more, disable unnecessary startup services, and run an occasional (every couple of months should be enough) defrag if you've got a mechanical hard drive.
If the world isn't making sense to you, you're either drinking too much or not drinking enough.