Mostly the problem is that the mouse isn't remotely close to the highlighted location
I had that problem to a smaller degree with my non-EyeFinity 7850, (Cat 12.7), but not the distorted cut-scene thing. Sorry I couldn't help more.
I was hoping for another patch because I also had a replicable bug that would present an interface with no usable action icons if you switched characters while in firing mode with gun without enough ammo (I think that was the sequence of actions).
Supposedly one will be out soon :/
I'm not going to try iron-man if I can completely goof up my game by doing actions in the wrong order.