I've got a 2TB WD Caviar Green and a 2TB Samsung HD204UI in mine. I'm certain that it can handle two programs recording and a third playing back without a hitch. I don't know that I've seen it recording four and playing back a fifth at the same time.
The 7200-rpm drives are noisier and hotter than the 5400/5900 rpm "green" drives. I put a 3TB Seagate Barracuda
in my gaming PC a couple of months ago for $140.
i7-6700K, NT06-Pro, GA-Z170N-Gaming5, 32 GiB, RX Vega56, SM951, 5TB HDD, Blu-ray, FTZ01, SX800-LTi, C32HG70, RK-9000BR, MX518