Cass, there's some development using Wine to get the GPU2 client working in Linux; I'm not sure how successful this effort has been but perhaps you can give it a read. Most of that stuff discussed in that thread is over my head but I'm sure you can sort it out better than I can.
Oh hell, I might try it, but I doubt it would be soon. linux 64 bit is a very large and troublesome pain in the ass. I would probably just try a 32 bit install and go from there since apparently the cuda runs in 32 bit binaries. Nothing ever works point and shoot in linux you mostly point shoot and then google and search for about six months trying to figure out what you shot and broke and then just reinstall and don't shoot the same target again. My current notfred 64 bit debian server has a broken kernel update thingamajig , and the update knows it needs to be updated, and I have been trying off and on for six months to fix it, I tried all kinds of build compile install mumbo jumbo, but nothing worked, its hopeless and at some point I must reinstall going to a new version, having to go to a new firewall/iptables/ipwhatever **** because it changes every six months with linux and what you used to use won't work anymore, and then I will have to navigate the dhcpd gauntlet.... linux sucks on so many levels. Then the method of conjuring up NAT/Masq will have changed and nobody will know it and you will have to search 45,000 more pages of google bs to find that one magical nugget of info that turns it on. All that after reading man pages across four monitors at one time so you can read across page breaks. After going through FreeBSD 4x-5.3, RH 3-5, debian, and knoppix.... I have grown to hate linux to the point DOS would make me happy. hell give me a 200 baud modem and VAX/VMS I would get more done (it didn't take a week to get X going). I feel like I have spent 4 years of my life reading man pages/googling for info, and everything I had working two months ago is guaranteed to never ever work again when the latest "killer linux" comes back out.
It would be a better use of my time to just buy ten copies of windows and install them. I could do that and be folding in about two hours... there is zero chance I would have linux installed succesfully in less than 40 hours. In my experience you have to install every version of linux about 4-6 times just to figure out what size to make the different partitions linux for whatever reason needs, and then invariably one partition loads up and kill the install and you have to start resizing partitions.