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Cancer Results

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PRIME1
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Cancer Results

Sun Jan 16, 2005 10:38 pm

http://folding.stanford.edu/news.html

1/15/2005 First results from Folding@Home cancer project published. We have been studying the p53 tumor surpressor and our first results on p53 have recently been published. To our knowledge, this is the first peer-reviewed results from a distributed computing project related to cancer. Thanks to the continued support of FAH donors, this is will be just the first of many cancer related works that will come from FAH.

The nature of our results can best be described in our paper. However, here's a brief summary of our results. Roughly half of all known cancers result from mutations in p53. Our first work in the cancer area examines the tetramerization domain of p53. We predict how p53 folds and in doing so, we can predict which amino acid mutations would be relevant. When compared with experiments, our predictions have appeared to agree with experiment and give a new interpretation to existing data
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FireGryphon
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Sun Jan 16, 2005 11:13 pm

This is why we all chip in.
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drfish
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Mon Jan 17, 2005 4:48 am

Good post! Thanks!
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Vyse
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Mon Jan 17, 2005 5:01 am

Wow, nice!
This has to be put in the next folding update!
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Niteslayer
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Mon Jan 17, 2005 7:03 am

AWESOME!!! :o
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Haggis!
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Mon Jan 17, 2005 11:20 am

"To our knowledge, this is the first peer-reviewed results from a distributed computing project related to cancer"

And THAT is exactly why I bailed on UD/GRID and joined F@H. Stanford seems to uderstand the importance of publishing peer reviewed articles.

Great to see!
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idchafee
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Mon Jan 17, 2005 11:50 am

Vyse wrote:
Wow, nice!
This has to be put in the next folding update!


I was going to take a week off from diseases (writing that Alzheimer's one was really depressing), but this seems like a perfect thing to put in there.
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NyteSkyy
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Mon Jan 17, 2005 12:13 pm

Awesome, just the encouragement I needed to build some more machines. :)
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drfish
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Mon Jan 17, 2005 12:15 pm

idchafee wrote:
Vyse wrote:
Wow, nice!
This has to be put in the next folding update!


I was going to take a week off from diseases (writing that Alzheimer's one was really depressing), but this seems like a perfect thing to put in there.


Missed the update somehow, just read it now, great work as always!
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meanfriend
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Mon Jan 17, 2005 12:19 pm

From the link, it was published in the Journal of Molecular Biology, which is a very respectable journal. Not the upper tier of journals like Science, or Nature, but a most excellent result nonetheless.

Anyone interested in getting the PDF? I can easily get it through work (I work in the pharmaceutical industry as a biochemist) and we have subscriptions to lots of journals.

It might not make for easy reading unless you are somewhat familiar with the biology, but since you guys put so much effort into folding, perhaps you might like to examine the fruits of your labors.

Plus, if you've never had occaision to view a published scientific paper, that might be interesting in itself.
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Stranger
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Mon Jan 17, 2005 2:05 pm

Hey I'd love a copy. just let me know how
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idchafee
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Tue Jan 18, 2005 10:09 am

I have a PDF of the entire article right here
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just brew it!
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Tue Jan 18, 2005 10:12 am

Very cool.
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meanfriend
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Tue Jan 18, 2005 12:11 pm

Awesome. Thanks for putting it up as I havent had a chance to download it at work yet...

BTW, where did you get it from?
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idchafee
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Tue Jan 18, 2005 12:14 pm

meanfriend wrote:
Awesome. Thanks for putting it up as I havent had a chance to download it at work yet...

BTW, where did you get it from?


Action Jim is a physicist at a national lab, he's got access to all the journals. He got it for me.
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Stranger
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Tue Jan 18, 2005 12:42 pm

Thanks a bunch
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liquidsquid
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Tue Jan 18, 2005 1:04 pm

Cool. Put that in your pipe and smoke it SETI!
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080119-deactivated
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Tue Feb 01, 2005 1:16 pm

Ah, this is why why Im folding(I didnt know it lol, I knew it was for a university, but not really for this kinda things). After reading this Ill go on folding, when Ive a new PC Ill get that one fold too(also my old one) 8) :wink: . I think this kinda progrmas is way better then going to people houses, ask for money and then make a advertisement on TV what costs LOTS of money. man, Im glad Im doing this :P

But, ALL the folds until now have solved this? Not Im saying its less, it takes lots of calculations to discover, but just curious what kinda CPU we need to get a problem calculated in just one second...

KEEP ON FOLDING ALL :P
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JediNinjaWizards
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Tue Feb 01, 2005 1:51 pm

Holy crap...so we're that much closer to possibly finding a cure for this terrible disease. So awesome. Science kicks ass! FOLD ON BITCHES!!!
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