If you're having trouble deciding which organization to support, let me recommend WorldVision. I'm no expert on these things, but I worked alongside some folks supported by WorldVision in Uganda years ago, and I can vouch for them as a real aid outfit with people in the field doing good work. Also, Amazon.com has a donation page for the American Red Cross relief efforts, complete with a counter showing a running total of the amount given. That seems to be an easy way to give, and watching the counter go up (just keep reloading) is mind-blowing.
Update: Check out the pictures from coastal Malaysia posted by zapgirl in this forum thread. Amazing.